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olanzapine originally branded zyprexa is an atypical antipsychotic.
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olanzapine monotherapy in adults in an analysis of 5 placebo controlled olanzapine monotherapy studies with treatment duration up to 12 weeks, olanzapine treated patients had statistically significant increases from baseline in mean fasting total cholesterol, ldl cholesterol, and triglycerides of 5.
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use olanzapine with caution in patients with cardiac disease or other conditions that may increase the risk of qt prolongation including cardiac arrhythmias, congenital long qt syndrome, heart failure, bradycardia, myocardial infarction, hypertension, coronary artery disease, hypomagnesemia, hypokalemia, hypocalcemia, or in patients receiving medications known to prolong the qt interval or cause electrolyte imbalances.
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in these same trials, olanzapine-treated patients n 2528 had a mean increase of 1 mg dl in cholesterol from a mean baseline value of 203 mg dl, which was significantly different compared to placebo-treated patients n 1420 with a mean decrease of 4 mg dl from a mean baseline value of 203 mg dl.
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both patients blood contained high concentrations of olanzapine, which can be dangerous and leads to the following symptoms delirium cardiopulmonary arrest cardiac arrhythmias reduced level of consciousness ranging from sedation to coma.
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